CADISS® System
Innovative surgical device
Selective dissection of pathological tissues and fibrosis
AuXin Surgery offers a safe & clinically validated system, the CADISS® System, that empowers surgeons to improve significantly the outcome of delicate surgical dissections.
How does it work ?
To achieve gentle and selective detachment, The CADISS® system is the direct combination of:
- non-aggressive irrigated mechanical blunt dissectors
- Deliver the CADISS® solution inside the surgical field through irrigated channels.
- Developed in collaboration with surgeons
- Adapted to the type of surgery and the tissues to be dissected.
- Similar tip design to existing surgical instruments.
- and the topical application of a CADISS® solution to weaken adherences
- Based on Mesna, well known thiol compound known to break disulfide bonds, used for decades as pharmaceutical drug (mucolytic & uroprotector).
- Specifically developed formulation optimized for application in the surgical field.
The combination between the mechanical force of the non-aggressive irrigated dissectors and the selective action of the CADISS® solution will enable an easy tissue separation, without damaging or tearing the pathological fibrotic tissue from the healthy structure to be preserved.
Quality of selective dissection with CADISS®
The cleavage plane between normal and pathological tissues is rich in fibrous proteins cross-linked by disulfide bonds, such bond being selectively targeted by CADISS®.
Therefore, the topical application of a CADISS® solution on the fibrotic adherence
- reveals the cleavage planes,
- reduces the adhesion of pathological tissues,
- facilitates their gentle detachment,
- avoids the use of cutting or aggressive instruments
Prerequisites to success

Contact time
Wait between 2 to 5 minutes to ensure enough contact time between the DADISS solution and the fibrotic tissue.

Mechanical action
Nothing is going to happen without the mechanical action of the non-aggressive dissector even with contact time.

Flat patient position
The CADISS solution is a liquid : arrange the surface or organize a cavity to ensure permanent contact without leaking.
Contra indications

Not for brain surgery
The use of CADISS® System for any surgery where the Mesna solution could be in contact with the brain, such as acoustic neuroma/vestibular schwannoma surgery or in presence of brain herniation into the mastoid, is strictly contraindicated. The topical application of Mesna into the inner-brain may cause severe epilepsy-like side-effects due to the disequilibrium in terms of electrolytes. Severe peripheral cerebral vasospasm has been also observed. In case of similar symptoms, consider the possibility of a pharmaceutical treatment of the patient with a Calcium antagonist such as Nimodipine.

Children and patients weighting less than 30 kg

Patients suffering from hepatic or renal disorders

Patients with a known hypersensitivity to mesna
Hypersensitivity to mesna may induce an acute syndrome of high fever and hemodynamic instability. these reactions disappear 8 to 24 hours after discontinuation of mesna
Safety Recommendations

Pregnant/breast feeding women
Use of CADISS® System is not recommended during pregnancy. Breast-feeding should be discontinued during treatment with CADISS® System.