CADISS® System

Innovative surgical device
Selective dissection of pathological tissues and fibrosis

AuXin Surgery offers a safe & clinically validated system, the CADISS® System, that empowers surgeons to improve significantly the outcome of delicate surgical dissections.

How does it work ?

To achieve gentle and selective detachment, The CADISS® system is the direct combination of:

  • non-aggressive irrigated mechanical blunt dissectors
    • Deliver the CADISS® solution inside the surgical field through irrigated channels.
    • Developed in collaboration with surgeons
    • Adapted to the type of surgery and the tissues to be dissected.
    • Similar tip design to existing surgical instruments.
  • and the topical application of a CADISS® solution to weaken adherences
    • Based on Mesna, well known thiol compound known to break disulfide bonds, used for decades as pharmaceutical drug (mucolytic & uroprotector).
    • Specifically developed formulation optimized for application in the surgical field.


The combination between the mechanical force of the non-aggressive irrigated dissectors and the selective action of the CADISS® solution will enable an easy tissue separation, without damaging or tearing the pathological fibrotic tissue from the healthy structure to be preserved.

Quality of selective dissection with CADISS®

The cleavage plane between normal and pathological tissues is rich in fibrous proteins cross-linked by disulfide bonds, such bond being selectively targeted by CADISS®.

Therefore, the topical application of a CADISS® solution on the fibrotic adherence

  • reveals the cleavage planes,
  • reduces the adhesion of pathological tissues,
  • facilitates their gentle detachment,
  • avoids the use of cutting or aggressive instruments

Prerequisites to success

Contact time

Wait between 2 to 5 minutes to ensure enough contact time between the DADISS solution and the fibrotic tissue.

Mechanical action

Nothing is going to happen without the mechanical action of the non-aggressive dissector even with contact time.

Flat patient position

The CADISS solution is a liquid : arrange the surface or organize a cavity to ensure permanent contact without leaking.

Contra indications

Not for brain surgery

The use of CADISS® System for any surgery where the Mesna solution could be in contact with the brain, such as acoustic neuroma/vestibular schwannoma surgery or in presence of brain herniation into the mastoid, is strictly contraindicated. The topical application of Mesna into the inner-brain may cause severe epilepsy-like side-effects due to the disequilibrium in terms of electrolytes. Severe peripheral cerebral vasospasm has been also observed. In case of similar symptoms, consider the possibility of a pharmaceutical treatment of the patient with a Calcium antagonist such as Nimodipine.

Children and patients weighting less than 30 kg

Patients suffering from hepatic or renal disorders

Patients with a known hypersensitivity to mesna

Hypersensitivity to mesna may induce an acute syndrome of high fever and hemodynamic instability. these reactions disappear 8 to 24 hours after discontinuation of mesna

Safety Recommendations

Pregnant/breast feeding women

Use of CADISS® System is not recommended during pregnancy. Breast-feeding should be discontinued during treatment with CADISS® System.